A mid-career crisis can happen to anyone. It can hit even those who objectively have the most fulfilling jobs. When it does, it inflicts pain on the individual suffering it and causes productivity losses for employers. Yet, the phenomenon remains stigmatized and under-researched, leaving crucial questions unanswered. What are the causes? Why does this malaise seem to strike in mid-life? And how can those who are stuck in its grips shake themselves loose?